Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives

For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism action as desirable candidates for potential drugs. However, this conventional strategy faced challenges including low success rate high costs. Herein, we critically review state-of-the-art based on multi-component Chinese medicine formulas. We policies application status new drugs medicines in US, China, European Union. Moreover, illustrate several excellent cases ongoing applications. Biomedical technologies that may facilitate formulas are discussed, network pharmacology, integrative omics, CRISPR gene editing, chemometrics. Finally, discuss problems solutions pre-clinical clinical research hope will promote discussion roles treatment human diseases.